Dr Tarryn Jacobs

Abstract:
Recent advances in the concepts of photoprotection have resulted in a more thorough understanding of the mechanism of photodamage. Current research suggests that UVA exposure can lead to the formation of ‘dark’ CPDs, which are DNA photoproducts that if not repaired can lead to mutations and ultimately to skin cancer. Several recent studies have also included the biological effects of visible light, shown to generate reactive oxygen and nitrogen species that can contribute to skin damage and pigmentation. Photoprotection by conventional sunscreens is exclusively prophylactic, and of no value, once DNA damage has occurred. Photoprotective agents, such as photolyases, may provide additional protection against UV radiation and visible-light-induced photodamage.