Prof Wayne Grayson is a speaker at the SCFSA online scientific meeting.

Topic: Epidermal squamoproliferative lesions challenges and controversies


AMPATH Laboratories, Johannesburg & School of Pathology, University of the
Witwatersrand, Johannesburg

Although well-differentiated endophytic epidermal squamoproliferative lesions are common, they frequently present diagnostic challenges for the Histopathologist. These challenges are magnified when an entire lesion is not represented, especially in the case of verrucous squamous cell carcinoma (SCC) or a proliferative actinic keratosis (AK).

Additional challenges are posed by correct recognition of a partially or fully regressed keratoacanthoma (KA), and the distinction between a KA proper and the KA-like variant of inverted follicular keratosis. Controversies surrounding KA and its relationship to SCC (including “follicular” SCC) appear to have been addressed by the most recent W.H.O. Classification of Skin Tumours.


AMPATH laboratories

Honorary Professor in the School of Pathology at WITS University, postgraduate teaching


Wits and S.A.I.M.R

Fellow of the College of Anatomical Pathologists of South Africa


University of the Free State

Medical degree

Prof Wayne Grayson history and accolades

Prof Wayne Grayson was born in Johannesburg, South Africa. He obtained his undergraduate medical degree from the University of the Free State in 1989.

Wayne received his specialist training in Anatomical Pathology at the University of the Witwatersrand (WITS) and the South African Institute for Medical Research (S.A.I.M.R.), and became a Fellow of the College of Anatomical Pathologists of South Africa in 1995.

He was a recipient of the James Gear prize and the Neville Proctor prize of the S.A.I.M.R. In 2001, Wayne was awarded a PhD from WITS University.

He headed the Dermatopathology service in the Division of Anatomical Pathology at WITS University and the National Health Laboratory Service in Johannesburg until 2008, when he joined AMPATH Laboratories.

His main areas of interest include infectious diseases of the skin, HIV/AIDS-related cutaneous pathology, and skin cancer – including melanoma and Kaposi sarcoma.

Wayne is a former Executive Committee member of the International Society of Dermatopathology, a founding member of the African Dermatopathology Society, and current Secretary of the International Committee for Dermatopathology.

He serves on the Editorial Board of the American Journal of Dermatopathology, among others.

He has delivered more than 100 invited lectures and slide seminars locally and abroad, and has published extensively. Wayne is a contributing author/co-author of several book chapters, including McKee’s Pathology of the Skin with Clinical Correlations, Kaposi Sarcoma: A Model of Oncogenesis, Hospital-Based Dermatopathology:

An Illustrated Guide to Evaluation and the recent W.H.O. publications on Tumours of the Skin and Soft Tissue and Bone Tumours. He was an active participant in the expert consensus meeting for the current W.H.O. Classification of Skin Tumours.

Wayne is an Honorary Professor in the School of Pathology at WITS University, where he remains actively involved in postgraduate teaching. He is the nominated recipient of the British Society of Dermatopathology’s Neil Smith Medal for 2021.